CAS NO: | 172377-52-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
20mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) is a potent, long-acting, and orally activesteroid sulfataseinhibitor; inhibits estrone sulfatase with anIC50of 251 nM and aKiof 133 nM. | ||||||||||||||||
IC50& Target | IC50: 251 nM (estrone sulfatase)[1] Ki: 133 nM (estrone sulfatase)[1] | ||||||||||||||||
体外研究 (In Vitro) | Introduction of a fluoro, chloro, or bromo moiety at the C-2 position of EMATE and Estradiol 3-sulfamate and that of a fluoro moiety at the C-4 position of the parent sulfamates markedly increase the estrone sulfatase inhibitory activity[1]. | ||||||||||||||||
体内研究 (In Vivo) | Estradiol 3-sulfamate is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, and both compounds have already been shown to be potent, long-acting, and orally active STS inhibitors[2]. | ||||||||||||||||
分子量 | 351.46 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H25NO4S | ||||||||||||||||
CAS 号 | 172377-52-5 | ||||||||||||||||
中文名称 | 雌二醇 3-氨基磺酸 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 62.5 mg/mL(177.83 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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