PERK-IN-4-d3 is the deuterium labeled PERK-IN-4. PERK-IN-4 is a potent and selectivePERK(protein kinase R (PKR)-like endoplasmic reticulum kinase) inhibitor with anIC₅₀of 0.3 nM.PERKis activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

472.45

C₂₄H₁₆D₃F₄N₅O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.