BAY-4931

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BAY-4931

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

423150-91-8

包装与价格：

产品介绍

BAY-4931 是一种有效的、共价的、选择性的PPARγ反向激动剂，IC₅₀为 0.17 nM。

生物活性

BAY-4931 is a potent, covalent and selectivePPARγinverse-agonist with anIC₅₀of 0.17 nM^[1].

IC₅₀& Target^[1]

PPAR-γ

0.17 nM (IC₅₀, RT112-FABP4-NLucP cellular reporter assay)

mouse PPARγ

0.14 nM (IC₅₀, GAL4-NHR-LBD one hybrid reporter assay )

hPPARγ

0.40 nM (IC₅₀, GAL4-NHR-LBD one hybrid reporter assay )

体外研究
(In Vitro)

BAY-4931 (0-10 μM; 7 days) inhibits UM-UC-9 proliferation with an IC₅₀of 3.4 nM^[1].
BAY-4931 only inhibits CYP2C8 in CYP inhibition test^[1].

Cell Proliferation Assay^[1]

Cell Line:	UM-UC-9 cells
Concentration:	0-10 μM
Incubation Time:	7 days
Result:	Inhibited proliferation with an IC₅₀of 3.4 nM.

分子量

421.83

Formula

C₂₂H₁₆ClN₃O₄

CAS 号

423150-91-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.