Leriglitazone

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Leriglitazone

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

146062-44-4

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议

产品名称

Hydroxypioglitazone

产品介绍

Leriglitazone (Hydroxypioglitazone)，吡格列酮的代谢产物。 Leriglitazone (Hydroxypioglitazone) 是PPARγ激动剂，通过稳定 PPARγ (AF-2) 共激活剂结合表面和增强共激活剂结合能力，提供高转录效力。 Leriglitazone（Hydroxypioglitazone) 与 PPARγC (LBD) 结合，其K_i值为 1.2 μM，诱导 PPARγ (LBD) 转录效率，EC₅₀为 680 nM。

生物活性

Leriglitazone (Hydroxypioglitazone), a metabolite of pioglitazone. Leriglitazone (Hydroxypioglitazone) PioOH is aPPARγagonist, stabilizes thePPARγactivation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone (Hydroxypioglitazone) binds to thePPARγC-terminal ligand-binding domain (LBD) with aK_iof 1.2 μM，Leriglitazone induces transcriptional efficacy of thePPARγ(LBD) with anEC₅₀of 680 nM^[1].

IC₅₀& Target

Ki: 1.2 μM (PPARγ LBD); EC: 680 nM (PPARγ LBD) (Leriglitazone)^[1]

分子量

372.44

性状

Solid

Formula

C₁₉H₂₀N₂O₄S

CAS 号

146062-44-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month