CAS NO: | 146062-46-6 |
包装: | 5mg |
市场价: | 7700元 |
生物活性 | Leriglitazone (Hydroxypioglitazone) hydrochloride, a metabolite of pioglitazone. Leriglitazone (Hydroxypioglitazone) hydrochloride PioOH is aPPARγagonist, stabilizes thePPARγactivation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone (Hydroxypioglitazone) hydrochloride binds to thePPARγC-terminal ligand-binding domain (LBD) with aKiof 1.2 μM,Leriglitazone induces transcriptional efficacy of thePPARγ(LBD) with anEC50of 680 nM[1]. | ||||||||||||||||
IC50& Target[1] |
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分子量 | 408.90 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C19H21ClN2O4S | ||||||||||||||||
CAS 号 | 146062-46-6 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 50 mg/mL(122.28 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |