CAS NO: | 141200-24-0 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Darglitazone (CP-86325), a thiazolidinedione, is a potent, selective, and orally activePPAR-γagonist. Darglitazone is effective in controlling blood glucose and lipid metabolism, and can be used for type II diabetes research[1]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | In cell lines representing white (3T3-L1 and 3T3-F442A) and brown (HIB-1B) adipose tissues and skeletal muscle (L6), within 4 h of exposing these cells to 30 μM Darglitazone, there is an increase in uncoupling protein 2 (UCP2) mRNA which reached a plateau of 5-10 times the basal in about 8 h. Darglitazone can stimulate the expression of UCP2 gene probably via PPAR-γ[2]. | ||||||||
体内研究 (In Vivo) | Darglitazone treatment restores euglycemia and normalized elevated corticosterone, triglycerides, and very-low-density lipoprotein levels. Darglitazone dramatically reduces the infarct size in the ob/ob mice at 24 h of recovery. Darglitazone treatment restores acute cerebral inflammatory responses that were absent in the diabetic mice and profoundly improved their recovery from hypoxic-ischemic (H/I) insult[1].
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分子量 | 420.48 | ||||||||
Formula | C23H20N2O4S | ||||||||
CAS 号 | 141200-24-0 | ||||||||
中文名称 | 达格列酮 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |