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Darglitazone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Darglitazone图片
CAS NO:141200-24-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
CP-86325
产品介绍
Darglitazone (CP-86325),一种噻唑烷二酮,是一种有效的,选择性的和具有口服活性的PPAR-γ激动剂。Darglitazone 有效控制血糖和脂质代谢,可用于 II 型糖尿病研究。
生物活性

Darglitazone (CP-86325), a thiazolidinedione, is a potent, selective, and orally activePPAR-γagonist. Darglitazone is effective in controlling blood glucose and lipid metabolism, and can be used for type II diabetes research[1].

IC50& Target[1]

PPAR-γ

 

体外研究
(In Vitro)

In cell lines representing white (3T3-L1 and 3T3-F442A) and brown (HIB-1B) adipose tissues and skeletal muscle (L6), within 4 h of exposing these cells to 30 μM Darglitazone, there is an increase in uncoupling protein 2 (UCP2) mRNA which reached a plateau of 5-10 times the basal in about 8 h. Darglitazone can stimulate the expression of UCP2 gene probably via PPAR-γ[2].

体内研究
(In Vivo)

Darglitazone treatment restores euglycemia and normalized elevated corticosterone, triglycerides, and very-low-density lipoprotein levels. Darglitazone dramatically reduces the infarct size in the ob/ob mice at 24 h of recovery. Darglitazone treatment restores acute cerebral inflammatory responses that were absent in the diabetic mice and profoundly improved their recovery from hypoxic-ischemic (H/I) insult[1].

Animal Model:Male diabetic ob/ob mice[1]
Dosage:1 mg/kg
Administration:Oral administration; daily; for 7 days
Result:Normalized blood glucose and reduced circulating triglycerides (TG) and very-low-density lipoproteins (VLDL) in diabetic ob/ob mice without having any effect in the nondiabetic mice.
分子量

420.48

Formula

C23H20N2O4S

CAS 号

141200-24-0

中文名称

达格列酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.