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Edaglitazone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Edaglitazone图片
CAS NO:213411-83-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
依格列宗
产品介绍
Edaglitazone 是一种有效,选择性和具有口服活性的PPARγ激动剂,对PPARαPPARγEC50值分别为 35.6 nM 和 1053 nM。Edaglitazone 显示出抗血小板、抗糖尿病和抗高血糖活性。
生物活性

Edaglitazone is a potent, selective and orally activePPARγagonist, withEC50s of 35.6 nM and 1053 nM forPPARαandPPARγ, respectively. Edaglitazone displays antiplatelet, antidiabetic and anti-hyperglycemic activity[1][2][3].

IC50& Target[1]

PPARγ

35.6 nM (EC50)

PPARα

1053 nM (EC50)

体外研究
(In Vitro)

Edaglitazone (3-16 μM; 5 min) inhibits the collagen (1.2 μg/mL)-induced platelet aggregation. Edaglitazone increases the intraplatelet levels of cAMP in a concentration dependent manner. Edaglitazone preventes the Collagen-induced intraplatelet levels of PPARγ decrease[3].

体内研究
(In Vivo)

Edaglitazone (4.4 mg/kg; p.o. daily for 10 days) enhances insulin sensitivity in obese rats[2].

分子量

464.56

Formula

C24H20N2O4S2

CAS 号

213411-83-7

中文名称

依格列宗

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.