HS 014 是一种有效的选择性黑皮质素 4 (MC4) 受体拮抗剂，对人 MC4、MC1、MC3 和 MC5 受体的 Kis 分别为 3.16、108、54.4 和 694 nM。
| Cas No. | 207678-81-7 |
| 化学名 | (R)-3-((Z)-((S)-2-((Z)-(((S)-1-((S)-1-((4S,5Z,8Z,10S,11Z,13S,14Z,16R,17E,19S,20Z,22S,23Z,25R)-19-((1H-imidazol-5-yl)methyl)-10-((1H-indol-3-yl)methyl)-22-(2-carboxyethyl)-13-(3-guanidinopropyl)-6,9,12,15,18,21,24-heptahydroxy-25-((Z)-(1-hydroxyethylidene) |
| Canonical SMILES | C/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N\[C@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/C/C(O)=N/1)([H])CC2=CNC3=CC=CC=C23)([H])CCCNC(N)=N)([H])CC4=CC5=CC=CC=C5C=C4)([H])CC6=CN=CN6)([H])CCC(O)=O)([H])CSSC[C@]1([H])C(N7CCC[C@@]7([H])C(N8CCC[C@@]8([H])/ |
| 分子式 | C71H94N20O17S2 |
| 分子量 | 1563.77 |
| 溶解度 | Soluble to 1 mg/ml in Water |
| 储存条件 | Desiccate at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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