Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibitsDNAtopoisomeraseIIactivities.

Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases^[1]. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts^[2].

Ellipticine (NSC 71795) treatment results in Ellipticine (NSC 71795)-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b₅protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b₅may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795)^[3].

246.31

C₁₇H₁₄N₂

519-23-3

玫瑰树碱；椭圆玫瑰树碱

• Alkaloids
• Indole Alkaloids

• Plants
• Apocynaceae
• Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

DMSO : 5.8 mg/mL(23.55 mM;Need ultrasonic and warming)