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T-2513 hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
T-2513 hydrochloride图片
CAS NO:187793-52-8
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
T-2513 hydrochloride 是一种选择性的拓扑异构酶 I (topoisomerase I) 抑制剂。T-2513 hydrochloride 与拓扑异构酶 I-DNA 复合物共价结合并使其稳定，且抑制 DNA 复制和 RNA 合成，最终导致细胞死亡。
生物活性

T-2513 hydrochloride is a selectivetopoisomeraseIinhibitor. T-2513 hydrochloride binds covalently to and stabilizes thetopoisomeraseI-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death[1].

IC50& Target[1]

Topoisomerase I

 

体外研究
(In Vitro)

SN-38 is the metabolite of T-2513 hydrochloride[1].
T-2513 hydrochloride has a broad cytotoxicity against a range of human tumor cell lines[2].

Cell Viability Assay[2]

Cell Line:WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells
Concentration:15.1-111.5 ng/mL
Incubation Time:24 hours
Result:Exhibited cytotoxicity against a panel of human tumor cell lines with GI50s of 32.1, 97.6, 38.6, 15.6, 111.5, 15.1, 34.0, and 50.9 ng/mL for WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells, respectively.
体内研究
(In Vivo)

T-2513 hydrochloride (1-100 mg/kg) shows Antitumor Activity against Walker-256 carcinoma[2].

Animal Model:Rats bearing Walker-256 carcinoma[2]
Dosage:1, 10, and 100 mg/kg
Administration:
Result:The ED50was 23 mg/kg.
分子量

485.96

Formula

C25H28ClN3O5

CAS 号

187793-52-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.