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TP3011
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TP3011图片
CAS NO:534605-74-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
CH0793011
产品介绍
TP3011 (CH0793011) 是 CH-0793076 的活性代谢产物 (metabolite),是与 SN38 等价的有效拓扑异构酶 I (topoisomerase I) 抑制剂。TP3011 在 IC50亚纳摩尔范围内可抵抗癌细胞系的生长。
生物活性

TP3011 (CH0793011) is an activemetaboliteof CH-0793076 and is a potent topoisomeraseI inhibitor equipotent as SN38[1]. TP3011 is againstcancercell lines growth with IC50s at the range sub-nanomolar in vitro[2].

IC50& Target[1]

Topoisomerase I

 

体外研究
(In Vitro)

TP3011 (0-100 nM; 72 hours) (compound 6c) inhibits cell proliferative activities against various human cancer cell lines, producing 50% inhibition (IC50) of cell growth of 0.85 nM; 8.5 nM; and 8.2 nM in HCT116, QG56, and NCI-H460 (NSCLC) cells, respectively[2].

Cell Proliferation Assay[2]

Cell Line:HCT116, QG56, and NCI-H460 (NSCLC) cells
Concentration:0-100 nM
Incubation Time:72 hours
Result:Was against human cancer cell lines, such as CRC and NSCLC cell lines.
分子量

474.51

Formula

C26H26N4O5

CAS 号

534605-74-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.