CAS NO: | 316173-57-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | SCH442416 is a potent, selective and brain-penetrant antagonist ofadenosine A2Areceptor (A2AR), withKis of 0.048 and 0.5 nM for human and rat A2AR respectively. SCH442416 displays more than 23000-fold selectivity over A1R, A2BR, and A3R (Ki=1111, 10000, and 10000 nM, respectively). SCH442416 can be used for imaging of adenosine A2Areceptors in rat and primate brain[1][2]. | ||||||||||||||||
IC50& Target | IC50: 0.048 nM (hA2AR), 0.5 nM (rA2AR)[1] | ||||||||||||||||
体外研究 (In Vitro) | SCH442416 is selective for A2AR (Ki=0.50 nM) in rat striatal membranes over A1R and A3R (Ki=1815 and >10000, respectively)[1]. | ||||||||||||||||
体内研究 (In Vivo) | SCH-442416 (0.017 mg/kg; i.p.) completely abrogates the CGS-21680-induced decrease in skeletal muscle injury[3]. | ||||||||||||||||
分子量 | 389.41 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C20H19N7O2 | ||||||||||||||||
CAS 号 | 316173-57-6 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 62.5 mg/mL(160.50 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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