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Nociceptin(1-13)NH2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nociceptin(1-13)NH2图片
CAS NO:178064-02-3
包装:1mg
市场价:830元

产品介绍
Nociceptin (1-13)NH2 是一种有效的 ORL1 受体(阿片受体样受体 1 受体,OP4)激动剂,对小鼠输精管的 pEC50 为 7.9,与大鼠前脑膜结合的 Ki 为 0.75 nM。
Cas No.178064-02-3
化学名(S,Z)-6-amino-N-((S,Z)-1-(((S,Z)-1-(((S,Z)-1-(((S)-6-amino-1-hydroxy-1-iminohexan-2-yl)imino)-5-guanidino-1-hydroxypentan-2-yl)imino)-1-hydroxypropan-2-yl)imino)-1,3-dihydroxypropan-2-yl)-2-((Z)-((2S,3Z,5S,6Z,9Z,11S,12Z,14S,15Z,18Z,21Z,23S)-23-amino-14-be
Canonical SMILESC[C@@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/C/N=C(O)/[C@](N)([H])CC1=CC=CC=C1)([H])CC2=CC=CC=C2)([H])[C@@](O)([H])C)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](C(O)=N)([H])CCCCN)([H])CCCNC(N)=N)(
分子式C61H100N22O15
分子量1381.59
溶解度Soluble to 0.67 mg/ml in 20% acetonitrile
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes[1][2].

References:
[1]. Varani K, et al. Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br J Pharmacol. 1998 Dec;125(7):1485-90.
[2]. Calo' G, et al. Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol. 2000 Apr;129(7):1261-83.