MRS5698

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MRS5698

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1377273-00-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

MRS5698 是一种选择性 G_i蛋白偶联 A₃腺苷受体 (A₃AR) 激动剂，对于人和小鼠 A₃AR 的K_i约为 3 nM。MRS5698 可用于疼痛和银屑病的研究。

生物活性

MRS5698 is a selective G_iprotein-coupledA₃adenosine receptor(A₃AR) agonist, withK_is of approximately 3 nM for human and mouse A₃AR, respectively. MRS5698 can be used for the research of pain and psoriasis^[1]^[2].

IC₅₀& Target^[1]

Adenosine A₃receptor

~3 nM (Ki)

体外研究
(In Vitro)

MRS5698 displays higher affinity and selectivity (>3000-fold) agonist A₃R vs. other adenosine receptor (ARs) in both human and mouse^[1].
MRS5698 (0.1-10 μM; 1 hours) induces a concentration-dependently robust A3R-mediated cAMP reduction in HEK-293T cells permanently expressing the A3R, regardless the illumination condition^[3].

体内研究
(In Vivo)

MRS5698 (3 nmol/day; intrathecal injection for 25 days) prevents Oxaliplatin-induced mechano-allodynia and hyperalgesia, and attenuates Oxaliplatin-induced NLRP3/IL-1β neuroinflammation^[2].
MRS5698 (1 mg/kg; i.p. at days 2, 3 ) reduces the IL-23 induced (IL23 injected in day 0, 1, 3) ear thickness of C57BL/6N mouse during the third and fourth experimental days^[3].

Animal Model:	Oxaliplatin-induced Male Sprague Dawley rats (200–250 g starting weight)^[2]
Dosage:	3 nmol/day
Administration:	Intrathecal injection for 25 days
Result:	Increased the value of mechanical paw withdrawal threshold in grams (PWT) in rat. Attenuated oxaliplatin-induced expression of NLRP3 and maturation of caspase 1 in the DH-SC. Reduced IL-1β levels in the spinal cord.

分子量

564.97

Formula

C₂₈H₂₃ClF₂N₆O₃

CAS 号

1377273-00-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.