PSB-10 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

591771-91-4

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议

产品介绍

PSB-10 hydrochloride 是一种有效的选择性人腺苷 A3 受体 (A₃AR) 拮抗剂，K_i值为 0.44 nM。PSB-10 hydrochloride 显示出对 hA₃AR 受体比对 rA₁，rA_2A，hA₁，hA_2A和 hA_2B受体 (K_i=805, 6040, 1700, 2700, 30000 nM) 超出 800 倍的选择性。PSB-10 hydrochloride 在小鼠中产生热痛觉过敏。

生物活性	PSB-10 hydrochloride is a potent and selective antagonist ofhuman adenosine A3 receptor (A₃AR), with aK_iof 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA₃over rA₁, rA_2A, hA₁, hA_2Aand hA_2Breceptors (K_i=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice^[1]^[2].
IC₅₀& Target	Ki: 0.44 nM (hA3AR)^[2]
体外研究 (In Vitro)	PSB-10 hydrochloride exhibits a subnanomolar K_ivalue (K_i=0.43 nM versus [³H]NECA) for A₃AR. In addition, R-8 is highly selective (>800-fold) versus the other AR subtypes^[1].
体内研究 (In Vivo)	PSB-10 hydrochloride (50-100 mg/kg; i.p.) dose-dependently decreases hot-plate response latencies in mice^[2].
分子量	435.14
Formula	C₁₆H₁₅Cl₄N₅O
CAS 号	591771-91-4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.