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Adenosine A1 receptor activator T62
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Adenosine A1 receptor activator T62图片
CAS NO:40312-34-3
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
Adenosine A1 receptor activator T62 是腺苷 A1 受体 (adenosine A1 receptor) 的变构增强剂。Adenosine A1 receptor activator T62 在急性疼痛的动物模型中产生抗伤害感受，并在炎性和神经损伤性疼痛的模型中降低超敏反应。
生物活性

Adenosine A1 receptor activator T62 is an allosteric enhancer ofadenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain[1][2][3].

IC50& Target

Adenosine A1 receptor[1]

体内研究
(In Vivo)

Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level[1].

Animal Model:Male SpragueDawley rats (250 g) after paw incision surgery[1]
Dosage:0.3 μg, 0.5 μg, 1 μg, and 3 μg
Administration:Intrathecal administration
Result:Produced a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. The ED40(95% confidence interval) was 0.77 (0.63-0.91) μg.
Clinical Trial
分子量

291.80

性状

Solid

Formula

C15H14ClNOS

CAS 号

40312-34-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month