CAS NO: | 91374-20-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
生物活性 | Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2receptor agonist with aKiof 29 nM forD2receptor. Ropinirole hydrochloride haspEC50s of 7.4, 8.4 and 6.8 for hD2, hD3and hD4receptors, respectively. Ropinirole hydrochloride has no affinity for the D1receptors. Ropinirole hydrochloride has the potential for Parkinson's disease[1][2]. | ||||||||||||||||
IC50& Target[1][2] |
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体外研究 (In Vitro) | Ropinirole hydrochloride has affinity for D3receptors of 10-20 fold higher than the D2and D4receptors. Ropinirole hydrochloride is weakly active at alpha 2-adrenoceptors and 5-HT2receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors[1][2]. | ||||||||||||||||
体内研究 (In Vivo) | Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory[2].
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Clinical Trial | |||||||||||||||||
分子量 | 296.84 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C16H25ClN2O | ||||||||||||||||
CAS 号 | 91374-20-8 | ||||||||||||||||
中文名称 | 盐酸罗匹尼罗 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 100 mg/mL(336.88 mM;Need ultrasonic) DMSO : 16.67 mg/mL(56.16 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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