(+)-Praeruptorin A 是前胡（也称为白花前胡）的主要生物活性成分。
| Cas No. | 73069-27-9 |
| 别名 | 白花前胡甲素 |
| Canonical SMILES | O=C1C=CC(C=CC2=C3[C@H](OC(C)=O)[C@H](OC(/C(C)=C\C)=O)C(C)(C)O2)=C3O1 |
| 分子式 | C21H22O7 |
| 分子量 | 386.4 |
| 溶解度 | DMF: 30 mg/ml,DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (+)-Praeruptorin A is a coumarin derivative originally isolated from P. praeruptorum. It prevents LPS-induced increases in IL-1β and TNF-α in a concentration-dependent manner when used at concentrations ranging from 6.25 to 100 µM and IL-6 at concentrations ranging from 25 to 100 µM. It inhibits potassium chloride-induced contraction of isolated rabbit trachea by 50 and 100% when used at concentrations of 4.8 and 30 µM, respectively. Topical administration of (+)-praeruptorin A (0.3 µmol/cm2) reduces edema by 22% in a croton oil mouse model of inflammation. |
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