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[Des-His1,Glu9] Glucagon
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
[Des-His1,Glu9] Glucagon图片
CAS NO:110121-11-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
[Des-His1,Glu9] Glucagon是一种有效的胰高血糖素受体系统多肽拮抗剂。[Des-His1,Glu9] Glucagon 增强胰岛细胞在葡萄糖刺激下释放胰岛素。[Des-His1,Glu9] Glucagon 可用于糖尿病的研究。
生物活性

[Des-His1,Glu9] Glucagon is a potentglucagon receptorsystempeptide antagonist. [Des-His1,Glu9] Glucagon enhances the glucose-stimulated release ofinsulinfrom pancreatic islet cells. [Des-His1,Glu9] Glucagon can be used to research diabetes[1].

IC50& Target

Glucagon Receptor[1]

体外研究
(In Vitro)

[Des-His1,Glu9] Glucagon (1 pM-100 μM) does not activate membrane-bound adenylate cyclase up to a concentration of 2×10-4molar in the cAMP assay on isolated rat liver membranes (from male Sprague Dawley rats)[1].

体内研究
(In Vivo)

[Des-His1,Glu9] Glucagon (3.6-4.0 μg/kg for rabbits, 1 mg/kg for rats; i.v.; single dosage) suppresses hyperglycemic effects in rabbits and rats[1].

Animal Model:New Zealand rabbits (2.8-3.8 kg; fasted for 18 hours)[1]
Dosage:3.6-4.0 μg/kg
Administration:i.v.; single dosage
Result:Suppressed hyperglycemic response of glucagon.
Animal Model:Male Wistar rats weighing [350-400 mg; hyperglycemia induced by i.p. injection of 65 mg/kgStreptozotocin(HY-13753)][1]
Dosage:1 mg/kg
Administration:Intravenously administration through the tail vein; single dosage
Result:Decreased blood glucose rapidly, and reduced hyperglycemic effect by 70% within 5 min.
分子量

3359.63

Formula

C148H220N40O48S

CAS 号

110121-11-4

Sequence Shortening

SQGTFTSEYSKYLDSRRAQDFVQWLMNT

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.