CAS NO: | 1092457-78-7 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | MM 419447, a linaclotide metabolite, is aguanylate cyclase-Cagonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C)[1]. | ||||||||||||||||
体外研究 (In Vitro) | MM 419447 exhibits high-affinity binding to T84 cells, resulting in a significant, concentration-dependent accumulation of intracellular cyclic guanosine-39,59-monophosphate (cGMP)[1]. | ||||||||||||||||
体内研究 (In Vivo) | MM 419447 (10 mg/kg; p.o.) treatment shows the Cmax, AUC0-6and t1/2values of 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively[1]
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分子量 | 1363.56 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C50H70N14O19S6 | ||||||||||||||||
CAS 号 | 1092457-78-7 | ||||||||||||||||
Sequence Shortening | CCEYCCNPACTGC (Disulfide bridge:Cys1-Cys6; Cys2-Cys10; Cys5-Cys13) | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 100 mg/mL(73.34 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
*以上所有助溶剂都可在本网站选购。 |