| CAS NO: | 146-56-5 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 500mg | 电议 |
| Cas No. | 146-56-5 |
| 别名 | 盐酸氟奋乃静 |
| 化学名 | 2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol dihydrochloride |
| Canonical SMILES | FC(F)(F)C1=CC(N(C2=CC=CC=C2S3)CCCN4CCN(CCO)CC4)=C3C=C1.Cl.Cl |
| 分子式 | C22H28Cl2F3N3OS |
| 分子量 | 510.44 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 5 mg/ml |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | EC50: 1.24 μM Fluphenazine is a dopamine D1 and D2 receptor inhibitor. Dopamine D1 and D2 receptor immunohistochemistry has been used to study the structure of the adult rat arcuate-median eminence complex, particularly in relation to the tubero-infundibular dopamine neurons. In vitro: Previous study showed that both phenothiazines of fluphenazine and perphenazine induced concentration-dependent loss in cell viability with EC50s to be 1.24 and 2.76 μM for fluphenazine and perphenazine, respectively. Moreover, fluphenazine at 1.0 μM and perphenazine at 1.0 and 3.0 μM could inhibit melanogenesis and decrease the content of microphthalmia-associated transcription factor. In addition, both fluphenazine and perphenazine at higher concentrations caused depletion of melanocytes antioxidant status, indicating oxidative stress induction [1]. In vivo: Systemic fluphenazine could effectively attenuate mechanical allodynia in rat neuropathic pain models at 0.03-0.3 mg/kg doses, which approximated those used in rodent models of psychosis. For antiallodynic effect, fluphenazine was able to effectively suppress the ectopic discharges in injured afferent fibers without affecting the propagation of action potentials in an ex-vivo DRG-nerve preparation from CCI rats [2]. Clinical trial: Fluphenazine, which is sold under the brand names Prolixin, is clinically used as an antipsychotic medication in the treatment of chronic psychoses such as schizophrenia. In addition, fluphenazine is about equal in effectiveness to low-potency antipsychotics (https://en.wikipedia.org/wiki/Fluphenazine). References: |
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