CAS NO: | 633283-39-3 |
包装 | 价格(元) |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | VU10010 is a potent, highly selective and allostericM4mAChRpotentiator with anEC50of 400 nM. VU10010 binds to an allosteric site on M4mAChRand increases affinity for acetylcholine and coupling to G proteins. VU10010 increases carbachol-induced depression of transmission at excitatory but not inhibitory synapses in the hippocampus[1]. | ||||||||||||||||
体外研究 (In Vitro) | VU10010 potentiates the M4response to acetylcholine 47-fold while having no activity at other mAChR subtypes (rM1, rM2, rM3or rM5). VU10010 causes an increase in affinity for ACh and M4-mediated [35S]GTPγS binding[1]. | ||||||||||||||||
分子量 | 345.85 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C17H16ClN3OS | ||||||||||||||||
CAS 号 | 633283-39-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 125 mg/mL(361.43 mM;Need ultrasonic) 配制储备液
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