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Methacholine bromide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Methacholine bromide图片
CAS NO:333-31-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Acetyl-β-methylcholine bromide
产品介绍
Methacholine (Acetyl-β-methylcholine) bromide 是一种有效的muscarinic-3 (M3)激动剂。Methacholine bromide 直接作用于平滑肌上的乙酰胆碱受体,导致支气管收缩和气道变窄。Methacholine bromide 对识别支气管高反应性 (BHR) 显示出高灵敏度。Methacholine bromide 可用于测量气道高反应性 (AHR),作为评估具有哮喘样症状和正常静息呼气流速的个体的诊断辅助[2]
生物活性

Methacholine (Acetyl-β-methylcholine) bromide is a potentmuscarinic-3 (M3)agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates[1][2][3][4].

体内研究
(In Vivo)

Methacholine bromide (0.5 μg/kg plus 5 μg/kg/min for 30 min) induces bronchoconstriction in dogs[4].
Methacholine bromide (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited by bradykinin (4-40 μg/kg; i.v.) in a a dose-dependent manner in mouse[5].

Animal Model:9-week female BALB/c mice[6]
Dosage:0.03, 0.1, 0.3, 1 mg/kg
Administration:I.v
Result:Induced severe bronchoconstriction.
Clinical Trial
分子量

240.14

Formula

C8H18BrNO2

CAS 号

333-31-3

中文名称

溴化乙酰甲胆碱

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.