CAS NO: | 1104080-42-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | SNT207858 is a selective, blood brain barrier penetrating, potent and orally activemelanocortin-4(MC-4)receptorantagonist. SNT207858 has anIC50of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1]. | ||||||||
IC50& Target | IC50: 22 nM (binding, MC-4 receptor), 11 nM (function, MC-4 receptor)[1] | ||||||||
体外研究 (In Vitro) | SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5[1]. | ||||||||
体内研究 (In Vivo) | SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice[1].
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分子量 | 689.54 | ||||||||
Formula | C32H45Cl4N5O3 | ||||||||
CAS 号 | 1104080-42-3 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |