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SNT-207858
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SNT-207858图片
CAS NO:1104080-42-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
SNT-207858 是一种选择性,可渗透血脑屏障的,有口服活性的黑皮质素 (melanocortin; MC-4) 受体拮抗剂,SNT-207858 抑制与 MC-4 受体结合,IC50为 22 nM。SNT-207858 抑制 MC-4 活性,IC50为 11 nM。
生物活性

SNT207858 is a selective, blood brain barrier penetrating, potent and orally activemelanocortin-4(MC-4)receptorantagonist. SNT207858 has anIC50of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1].

IC50& Target

IC50: 22 nM (binding, MC-4 receptor), 11 nM (function, MC-4 receptor)[1]

体外研究
(In Vitro)

SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5[1].

体内研究
(In Vivo)

SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice[1].

Animal Model:Mice with C26 adenocarcinoma-induced cachexia model[1]
Dosage:30 mg/kg
Administration:Oral administration; once daily; 15 days
Result:Significantly reduced the tumor induced weight loss.
分子量

689.54

Formula

C32H45Cl4N5O3

CAS 号

1104080-42-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.