(p-Iodo-Phe7)-ACTH(4-10)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

159600-82-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

(p-Iodo-Phe7)-ACTH (4-10) 是肾上腺皮质激素 (ACTH) 的衍生物，由垂体前腺产生和分泌。(p-Iodo-Phe7)-ACTH (4-10) 作为黑素皮质素 (MC) 受体拮抗剂，抑制 α-黑素细胞刺激激素 (α-MSH) 诱导的大鼠过度梳理行为。

生物活性

(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats^[1].

体外研究
(In Vitro)

(p-Iodo-Phe7)-ACTH (4-10) (1 μM) exhibits inhibition of α-MSH-induced (1 nM-1 μM) cAMP accumulation in 293 HEK cells expressing either the rat melanocortin MC₃, human melanocortin MC₄or ovine melanocortin MC₅receptor^[1].
[Phe-I⁷]ACTH(4-10) has higher affinity for the MC₃, MC₄, and MC₅receptors but lower for the MC₁compared to ACTH(4-10)^[2].

体内研究
(In Vivo)

(p-Iodo-Phe7)-ACTH (4-10) (15 μg per animal; i.c.v.; single dose) blocks the a-MSH-induced excessive grooming behavior in rats^[1].

Animal Model:	Male Wistar rats (150 g)^[1]
Dosage:	1.5 or 15 μg per animal, mixed with 1.5 μg α-MSH or not
Administration:	Intracerebroventricular injection; one week prior to the experiment
Result:	Didn’t induce excessive grooming behavior by single dose. Inhibited the induction of excessive grooming behavior by a-MSH.

分子量

1087.98

Formula

C₄₄H₅₈IN₁₃O₁₀S

CAS 号

159600-82-5

Sequence Shortening

MEH-{p-Iodo-Phe}-RWG

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.