CAS NO: | 7266-47-9 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
生物活性 | ACTH (1-17), an adrenocorticotropin analogue, is a potenthuman melanocortin 1 (MC1) receptoragonist with aKiof 0.21 nM. | ||||||||||||||||||||
IC50& Target | Ki: 0.21 nM (human MC1 receptor)[1] | ||||||||||||||||||||
体外研究 (In Vitro) | ACTH (1-17) is a potent agonist at the hMC1R. ACTH (1-17) shows high affinity for the hMC1R with a Kivalue of 0.21±0.03 nM which is slightly higher than that of 0.13±0.005 nM for alpha-MSH[1]. ACTH (1-17) induces a slight and not significant increase in growth hormone secretion even when micromolar concentrations of the peptide are employed in rat pituitary cultures[2]. | ||||||||||||||||||||
体内研究 (In Vivo) | Inhibition of DNA labeling is noted when the ACTH (1-17) is administered at 2 hr after the beginning of the daily dark span when nocturnal animals become active. When administered at this circadian stage, the larger dose in particular is associated with an inhibition of DNA labeling lasting for 24 hr. The inhibitory effect is much shorter when the same dose is injected 4 hr earlier[3]. | ||||||||||||||||||||
分子量 | 2093.41 | ||||||||||||||||||||
Formula | C95H145N29O23S | ||||||||||||||||||||
CAS 号 | 7266-47-9 | ||||||||||||||||||||
Sequence | Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg | ||||||||||||||||||||
Sequence Shortening | SYSMEHFRWGKPVGKKR | ||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. | ||||||||||||||||||||
Solvent & Solubility | In Vitro: H2O Peptide Solubility and Storage Guidelines: 1. Calculate the length of the peptide. 2. Calculate the overall charge of the entire peptide according to the following table:
3. Recommended solution:
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