L-AP4

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L-AP4

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

23052-81-5

包装与价格：

包装	价格(元)
10 mM * 1 mL in Water	电议
5mg	电议
10mg	电议

产品名称

L-APB

产品介绍

L-AP4 (L-APB) 是一种有效的、代谢型谷氨酸受体(mGluR)的特异性激动剂，其对 mGlu₄, mGlu₈, mGlu₆和 mGlu₇受体的EC₅₀值分别为 0.13, 0.29, 1.0, 249 μM。

生物活性

L-AP4 (L-APB) is a potent and specific agonist for thegroup III mGluRs, withEC₅₀sof 0.13, 0.29, 1.0, 249 μM for mGlu₄, mGlu₈, mGlu₆and mGlu₇receptors, respectively^[1]^[2].

IC₅₀& Target

mGlu₄

0.13 μM (EC₅₀)

mGlu8

0.29 μM (EC₅₀)

mGlu₆

1.0 μM (EC₅₀)

mGlu7

249 μM (EC₅₀)

体内研究
(In Vivo)

L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction^[2].
Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats^[2].
Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion^[2].

Animal Model:	Rats.^[2]
Dosage:	5-30 μg.
Administration:	Intrathecal inhection 4-5 days.
Result:	Dose-dependently increased paw withdrawal threshold.

分子量

183.10

性状

Solid

Formula

C₄H₁₀NO₅P

CAS 号

23052-81-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 50 mg/mL(273.07 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	5.4615 mL	27.3075 mL	54.6150 mL
5 mM	1.0923 mL	5.4615 mL	10.9230 mL
10 mM	0.5461 mL	2.7307 mL	5.4615 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。