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DCG-IV
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DCG-IV图片
CAS NO:147782-19-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
DCG-IV 是一种有效的 II 类mGluRs受体激动剂,对 mGlu2R 和 mGlu3R 的EC50值为 0.35 和 0.09 μM。DCG-IV 也是 I 组 (IC50: mGlu1R/5R=389/630 μM) 和 III 组受体 (IC50: mGlu4R/6R/7R/8R=22.5/39.6/40.1/32 μM) 的竞争性拮抗剂。DCG-IV 具有抗惊厥和神经保护作用。
生物活性

DCG-IV is a potent agonist of group IImGluRswithEC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects[1][2].

IC50& Target[1]

mGluR2R

0.35 μM (EC50)

mGluR3R

0.09 μM (EC50)

mGluR1R

389 μM (IC50)

mGluR5

630 μM (IC50)

mGluR4R

22.5 μM (IC50)

mGluR6

39.6 μM (IC50)

mGluR7

40.1 μM (IC50)

mGluR8

32 μM (IC50)

体外研究
(In Vitro)

DCG-IV is also an NMDA receptor agonist in the rat cortical slice[3].

体内研究
(In Vivo)

DCG-IV (1-10 mg/kg; i.p.) depresses the phencyclidine (PCP)-induced hyperlocomotion[4].

Animal Model:Male ICR mice weighing about 40 g (PCP-induced locomotor activity)[4]
Dosage:10, 5, or 1 mg/kg
Administration:I.p.
Result:Reduced spontaneous activities of the animals at 10 or 5 mg/kg.
分子量

203.15

Formula

C7H9NO6

CAS 号

147782-19-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.