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(RS)-MCPG
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(RS)-MCPG图片
CAS NO:146669-29-6
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
alpha-MCPG
产品介绍
(RS)-MCPG (alpha-MCPG) 是一种竞争性和选择性 I/II 组代谢型谷氨酸受体 (mGluR) 拮抗剂。(RS)-MCPG 阻断 TBS 诱导的幼年和新生大鼠海马神经元的转变。
生物活性

(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group IImetabotropic glutamate receptor (mGluR)antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons[1][2].

IC50& Target

group I/group II mGluR[1]

体外研究
(In Vitro)

MCPG can block group I (mGluR1 and mGluR5) and group II receptors (mGluR2 and mGluR3)[2].

体内研究
(In Vivo)

(RS)-MCPG (alpha-MCPG; 500 μM) blocks the TBS-induced shifts in EGABA in either juvenile or neonatal neurons[1].
Pretreatment with the low dose of (RS)-MCPG (25 nM; i.c.; daily; 5 days) significantly attenuates amphetamine-induced locomotor activity in 10-day-old male and female rats of Sprague-Dawley descent[2].

分子量

209.20

性状

Solid

Formula

C10H11NO4

CAS 号

146669-29-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

1M NaOH : 100 mg/mL(478.01 mM;ultrasonic and adjust pH to 10 with NaOH)

DMSO : 6 mg/mL(28.68 mM;Need ultrasonic and warming)

H2O :< 0.1 mg/mL (ultrasonic;heat to 80℃)(insoluble)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM4.7801 mL23.9006 mL47.8011 mL
5 mM0.9560 mL4.7801 mL9.5602 mL
10 mM0.4780 mL2.3901 mL4.7801 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。