您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > MSOP
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
MSOP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MSOP图片
CAS NO:66515-29-5
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
5mg电议
10mg电议
50mg电议

产品介绍
MSOP 是第三组代谢性谷氨酸受体的选择性拮抗剂,其对 L-AP4 敏感突触前代谢性谷氨酸受体的 KD值为 51 μM。
生物活性

MSOP is a selectivegroup III metabotropic glutamate receptorantagonist with apparentKDof 51 μM for the L-AP4-sensitive presynapticmGluR.

IC50& Target

KD: 51 μM (L-AP4-sensitive presynaptic mGluR)[1].

体外研究
(In Vitro)

In the presence of 200 μM MSOP, a rightward parallel shift of the dose-response curve to L-AP4 is observed, with an apparent KDcalculated as 51±6 μM (n=3). MSOP is shown to be selective for the L-APC sensitive presynaptic mGluR, the apparent KDfor the interaction of MSOP with the (1S, 3S)-ACPD sensitive receptor calculated as greater than 700 μM (n=3)[1].

体内研究
(In Vivo)

It is found that TBOA-induced antinociceptive effects are significantly blocked by intrathecal co-administration of MSOP (second phase of formalin model: F3,16=30.96, P<0.001; CFA model: F3,16=30.77, P<0.001). As expected, intrathecal TBOA (10 μg) reduces the number of formalin-induced flinches and shakes by 47% of the value in the saline-treated group in the second phase (P<0.001) and blocked the CFA-induced decrease in ipsilateral paw withdrawal latency by 60% of the value in the saline-treated group (P=0.01). The number of formalin-induced flinches in the second phase in the group treated with MSOP and TBOA is increased by 56% (P=0.04) of the value in the TBOA-treated group. CFA-induced paw withdrawal latency in the group treated with MSOP and TBOA is decreased by 86% (P=0.03) of the value in the TBOA-treated group[2].

分子量

199.10

性状

Solid

Formula

C4H10NO6P

CAS 号

66515-29-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

H2O : 19 mg/mL(95.43 mM;Need ultrasonic and warming)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM5.0226 mL25.1130 mL50.2260 mL
5 mM1.0045 mL5.0226 mL10.0452 mL
10 mM0.5023 mL2.5113 mL5.0226 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。