CAS NO: | 83027-13-8 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | AMN082 free base, a selective, orally active, and brain penetrantmGluR7agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50values, 64-290 nM) at transfected mammalian cells expressingmGluR7. AMN082 free base shows selectivity over othermGluRsubtypes and selected ionotropic glutamate receptors. Antidepressant effects[1][2]. | ||||||||||||||||
IC50& Target | mGluR7[1] | ||||||||||||||||
体外研究 (In Vitro) | Preincubation of the synaptosomes with AMN082 (1 μM) for 10 min before 4-aminopyridine treatment efficiently inhibits the 4-aminopyridine-evoked release of glutamate, without altering the basal release of glutamate[2]. | ||||||||||||||||
体内研究 (In Vivo) | AMN082 (6 mg/kg; p.o.) induces stress hormone increases in an mGluR7-dependent fashion in mGluR7+/+mice (C57BL/6 genetic background)[1]. | ||||||||||||||||
分子量 | 392.54 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C28H28N2 | ||||||||||||||||
CAS 号 | 83027-13-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 12.5 mg/mL(31.84 mM;ultrasonic and warming and heat to 60℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
*以上所有助溶剂都可在本网站选购。 |