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BMT-145027
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BMT-145027图片
CAS NO:2018282-44-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议

产品介绍
BMT-145027是mGluR5的正变构调节物且没有固有的激动剂活性,EC50值为47 nM。
生物活性

BMT-145027 is anmGluR5positive allosteric modulator without inherent agonist activity, exhibits anEC50of 47 nM.

IC50& Target[1]

mGluR5

47 nM (EC50)

体外研究
(In Vitro)

BMT-145027 is a compound with high MsLM stability (85% remaining), acceptable potency (EC50=47 nM), and a modest decrease in planarity (Fsp3 = 0.17). Importantly, BMT-145027 lacks inherent mGluR5 agonist activity when tested at concentrations up to 16 μM[1].

体内研究
(In Vivo)

Drug-treated and control mice are shown two identical objects. After a 24-h natural forgetting period, the mice are reintroduced to a familiar object while simultaneously presented with a novel object. Since mice spend more time exploring unfamiliar objects, improved memory is measured as time spent exploring the novel object. BMT-145027 leads to a significant increase in time spent with the novel object when dosed at 30 mg/kg, with an apparent trend in novel object preference at 10 mg/kg. Satellite animals indicates a total plasma concentration of 2800 nM at 30 mg/kg[1].

分子量

438.83

性状

Solid

Formula

C23H14ClF3N4

CAS 号

2018282-44-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 2.4 mg/mL(5.47 mM;Need ultrasonic and warming)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.2788 mL11.3939 mL22.7879 mL
5 mM0.4558 mL2.2788 mL4.5576 mL
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。