mGluR5 modulator 1 是一个mGluR5阳性变构调节剂。mGluR5 modulator 1 可用于精神分裂症和认知功能障碍的研究。
生物活性 | mGluR5 modulator1 is amGluR5positive allosteric modulator.mGluR5 modulator1 can be used for the research of the schizophrenia and cognitive impairments[1]. |
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体外研究 (In Vitro) | mGluR5 modulator 1 (compound 2c; 0.1-0.00001 nM) potentiates the L-glutamate and DHPG responses to the same maximum response as the orthosteric agonists alone in the Ca2+mobilization and IP1 accumulation assays[1]. mGluR5 modulator 1 (0.1-0.00001 nM) potentiates the L-glutamate and DHPG responses above the orthosteric agonist maximal response in the ERK1/2 phosphorylation assay[1]. mGluR5 modulator 1 induces mGlu5 internalization in the absence of add orthosteric agonist or antagonist[1]. mGluR5 modulator 1 potentiates the responses induced by both orthosteric agonists (L-glutamate or DHPG) in Ca2+mobilization (pKB=5.4 and 5.3, respecyively), inositol monophosphate accumulation, and ERK1/2 phosphorylation signaling (pKB=5.88 and 5.4, respecyively) assays in HEK293A-mGlu5-low cells[1]. mGluR5 modulator 1 enhances the effect of DHPG in cortical neurons with pEC50values of 6.32 and 6.33 in Ca2+mobilization and inositol monophosphate (IP1) accumulation assays[1].
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运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |