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CPPG
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CPPG图片
CAS NO:183364-82-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
(RS)-CPPG
产品介绍
CPPG ((RS)-CPPG) 是一种有效的 II/III 型mGlu受体拮抗剂。CPPG 对大鼠大脑皮层中的 III 组 (IC50=2.2 nM) 比对 II 组((IC50=46.2 nM) mGlu 受体有一定的选择性 (约 20 倍)。CPPG 对 I 组 mGlu 受体的作用较弱。
生物活性

CPPG ((RS)-CPPG) is a potent group II/IIImGlu receptorsantagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors[1].

IC50& Target[1]

group III mGlu receptors

2.2 nM (IC50)

group II mGlu receptors

46.2 nM (IC50)

体外研究
(In Vitro)

CPPG ((RS)-CPPG) potently reversed both L-AP4 (IC50=2.2 nM)- and L-CCG-I (IC50=46.2 nM) -mediated inhibition of forskolin-stimulated cyclic AMP accumulation in adult rat cortical slices. CPPG is a potent antagonist against group II/III mGlu receptors in the adult rat cortex and shows moderate selectivity for group III mGlu receptors. Conversely, CPPG has weak effects at group I mGlu receptors in both the neonatal rat cortex and cultured cerebellar granule cells[1].

分子量

271.21

Formula

C11H14NO5P

CAS 号

183364-82-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.