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VU-1545
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VU-1545图片
CAS NO:890764-63-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
VU-1545 是一种代谢型谷氨酸受体 5 正变构调节剂 (mGluR5 PAM),Ki为 156 nM,EC50为 9.6 nM。
生物活性

VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5PAM) with aKiof 156 nM and anEC50of 9.6 nM[1].

IC50& Target

mGluR5

156 nM (Ki)

mGluR5

9.6 nM (EC50)

体外研究
(In Vitro)

VU-1545 (10 and 100 μM) promotes AKT activation. VU-1545 at the concentrations of 0.1 and 1.0 μM efficiently promots Akt activation above basal levels[2].

Western Blot Analysis[2]

Cell Line:Neuronal cells
Concentration:10 and 100 μM
Incubation Time:5 minutes
Result:Promoted Akt phosphorylation as efficiently at the concentration of 10.0 μM as at the concentration of 100.0 μM.
分子量

402.38

Formula

C22H15FN4O3

CAS 号

890764-63-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.