MFZ 10-7 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1779796-36-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

MFZ 10-7 hydrochloride 是一种高效选择性的mGluR5负变构调节剂 (NAM)，对大鼠 mGluR5 作用的K_i值为 0.67 nM。MFZ 10-7 hydrochloride 可以抑制大鼠可卡因成瘾。

生物活性

MFZ 10-7 hydrochloride is a highly potent and selectivemGluR5NAM (negative allosteric modulator), with aK_iof 0.67 nM for ratmGluR5. MFZ 10-7 hydrochloride inhibits cocaine-taking and cocaine-seeking behavior in rats^[1].

IC₅₀& Target

rat mGluR5

0.67 nM (Ki)

体外研究
(In Vitro)

MFZ 10-7 hydrochloride has approximately 1150- and 3000-fold lower affinity for MAO-B (monoamine oxidase-B enzyme) and TXA2 (thromboxane A2 receptor), respectively, compared to mGluR5^[1].

体内研究
(In Vivo)

MFZ 10-7 hydrochloride (3 mg/kg, 10 mg/kg; i.p.) inhibits cocaine self-administration in rats^[1].
MFZ 10-7 hydrochloride can lower oral sucrose self-administration rate but has no effect on total sucrose intake^[1].

Animal Model:	Male Long-Evans rats (250-300 g)^[1]
Dosage:	3 mg/kg, 10 mg/kg
Administration:	Intraperitoneal injection, single injection
Result:	Dose-dependently shifted the cocaine dose-response curve downward and inhibited cocaine self-administration maintained by a high dose (0.5 mg/kg/infusion) of cocaine.

分子量

272.70

Formula

C₁₅H₁₀ClFN₂

CAS 号

1779796-36-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.