Argipressin diacetate

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CAS NO:

75499-44-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

Arg8-vasopressin diacetate
AVP diacetate
ADH

产品介绍

Argipressin (diacetate) (AVP (diacetate)，又称antidiuretic hormone (ADH)) 是由垂体后叶分泌的 9 个氨基酸神经肽。Argipressin (diacetate) (AVP (diacetate)) 可通过三个独立的 G 蛋白偶联受体(GPCRs)，即 Avpr1a (V1a)、Avpr1b (V1b) 和 Avpr2 (V2)，调节体液平衡、渗透压和心血管的生物学效应。Argipressin (diacetate) (AVP (diacetate)) 对中枢调节代谢过程也有潜在的重要影响。

生物活性

Argipressin (diacetate) (AVP (diacetate), also known as antidiuretic hormone (ADH)) is a 9amino acid neuropeptidesecreted by the posterior pituitary. Argipressin (diacetate) (AVP (diacetate)) can regulate the biological effects of fluid balance, osmolality and cardiovascular through three separate G-protein coupled receptors (GPCRs), namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2). Argipressin (diacetate) (AVP (diacetate)) also have potentially important effects on centrally regulated metabolic processes^[1].

体外研究
(In Vitro)

Argipressin (diacetate) (AVP (diacetate)) induces proliferation and prevented cytokine-induced apoptosis in rodent and human beta-cells^[1].

Cell Proliferation Assay^[1]

Cell Line:	clonal BRIN BD11 and 1.1B4 cells
Concentration:	10^-6M
Incubation Time:	2 h
Result:	Increased proliferation of rodent and human beta-cells.

Apoptosis Analysis^[1]

Cell Line:	clonal BRIN BD11 and 1.1B4 cells
Concentration:	10^-6M
Incubation Time:	2 h
Result:	Protected against cytokine-induced beta-cell apoptosis.

体内研究
(In Vivo)

Argipressin (diacetate) (AVP (diacetate)) (25 nmol/kg bw; intraperitoneal injection; once) significantly reduces overall AUC glucose values，but not increases insulin levels in mice^[1].

Animal Model:	NIH Swiss mice (adult; male; 12-14weeks)^[1]
Dosage:	25 nmol/kg bw
Administration:	AVP (25 nmol/kg bw; intraperitoneal injection; once)
Result:	Reduced (P<0.001) overall AUC glucose values，but not increased insulin levels in mice.

Clinical Trial

分子量

1204.34

Formula

C₅₀H₇₃N₁₅O₁₆S₂

CAS 号

75499-44-4

Sequence Shortening

CYFQNCPRG-NH2 (Disulfide bridge: Cys1-Cys6)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.