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Galanin Receptor Ligand M35 TFA
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Galanin Receptor Ligand M35 TFA 是一种高亲和力的甘丙肽受体 (galanin receptor) 配体 (Kd=0.1 nM)，也是galanin receptor拮抗剂。Galanin Receptor Ligand M35 TFA 对人甘丙肽受体 1 型 和 人甘丙肽受体 2 型 的Ki值分别为 0.11 nM、2.0 nM。
生物活性

GalaninReceptor Ligand M35 TFA is a high-affinity ligand and antagonist ofgalaninreceptor(Kd=0.1 nM).GalaninReceptor Ligand M35 TFA exerts aKivalues of 0.11 and 2.0 nM for humangalaninreceptor type 1 and 2, respectively[1][2].

体外研究
(In Vitro)

Galanin Receptor Ligand M35 TFA has a dual effect on the galanin mediated inhibition of Forskolin stimulated cyclic AMP production in Rin m 5F cells. Co-applied with galanin (10 nM), Galanin Receptor Ligand M35 TFA at low concentrations (1 nM) is able to reverse the inhibitory effect of galanin. But when present at higher concentrations (15 and 30 nM), Galanin Receptor Ligand M35 TFA acts as a galanin receptor agonist, inhibiting the forskolin stimulated production of cAMP[1].

体内研究
(In Vivo)

Galanin Receptor Ligand M35 TFA (6 nM/10 μL; i.c.v.) improves the ability of the male Sprague-Dnwley rats to acquire the swim maze task[3].

分子量

2347.62

Formula

C109H154N27F3O28

Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-NH2

Sequence Shortening

GWTLNSAGYLLGPPPGFSPFR-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.