CAS NO: | 1383577-62-5 |
包装: | 2mg |
市场价: | 800元 |
生物活性 | Alvimopan monohydrate (ADL 8-2698 monohydrate) is a potent, selective, orally active and reversibleμ-opioid receptorantagonist, with anIC50of 1.7 nM. Alvimopan monohydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) overκ-andδ-opioid receptors(Kis=100, 12 nM, respectively). Alvimopan monohydrate can be used for the research of postoperative ileus[1][2][3]. | ||||||||||||
IC50& Target | IC50: 1.7 nM (μ-opioid receptor)[1] | ||||||||||||
体外研究 (In Vitro) | Alvimopan inhibits the loperamide-stimulated [35S]GTPγS binding to membranes containing the cloned human μ-opioid receptor, with an IC50of 1.7 nM[1]. | ||||||||||||
体内研究 (In Vivo) | Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of113Sn-labelled microspheres produced by morphine in rats[3]. | ||||||||||||
Clinical Trial | |||||||||||||
分子量 | 442.55 | ||||||||||||
性状 | Solid | ||||||||||||
Formula | C25H34N2O5 | ||||||||||||
CAS 号 | 1383577-62-5 | ||||||||||||
中文名称 | 爱维莫潘水合物 | ||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
储存方式 |
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