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JDTic
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JDTic图片
CAS NO:361444-66-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
JDTic是κ-阿片受体拮抗剂,对μ-和δ-阿片受体无作用。
生物活性

JDTic is a highly selective antagonist for the κ-opioid receptor; without affecting the μ- or δ-opioid receptors. IC50 value: Target: κ-opioid receptor JDTic is a 4-phenylpiperidine derivative, distantly structurally related to analgesic drugs such as meperidine and ketobemidone, and more closely to the mu opioid antagonist alvimopan, and is structurally distinct from other kappa antagonists such as norbinaltorphimine. JDTic has a very long duration of action, with effects inanimalsseen for up to several weeks after administration of a single dose, although its binding to the kappaopioid receptoris not irreversible and its long-acting effects are instead caused by altered activity of c-Jun N-terminal kinases. Animal studies suggest that it may produce antidepressant and anxiolytic effects, as well as having possible application in the treatment of addiction to cocaine and morphine.

Clinical Trial
分子量

465.63

Formula

C28H39N3O3

CAS 号

361444-66-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.