| CAS NO: | 202801-92-1 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 生物活性 | Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist atOrexinreceptor withKis of 420 and 36 nM for OX1 and OX2, respectively. | ||||||||||||||||
| IC50& Target | Ki: 420 nM (OX1), 36 nM (OX2)[1] | ||||||||||||||||
| 体外研究 (In Vitro) | OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50of 36 nM in the binding assay and an EC50of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50in the competitive binding assay and the EC50in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2]. | ||||||||||||||||
| 体内研究 (In Vivo) | Orexin-B modulates the activity of rod bipolar cells (RBCs) located in the outer retina of rat. Intravitreal injection of orexin-B increased the amplitude of the scotopic electroretinographic b-wave, a reflection of RBC activity, recorded in vivo[4]. | ||||||||||||||||
| 分子量 | 2936.40 | ||||||||||||||||
| 性状 | Solid | ||||||||||||||||
| Formula | C126H215N45O34S | ||||||||||||||||
| CAS 号 | 202801-92-1 | ||||||||||||||||
| Sequence | Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 | ||||||||||||||||
| Sequence Shortening | RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2 | ||||||||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
| 储存方式 | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
| 溶解性数据 | In Vitro: H2O : 16.67 mg/mL(5.68 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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