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Orexin B,rat,mouse TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品名称
Rat orexin B TFA
Orexin B (mouse) (TFA)
产品介绍
Orexin B, rat, mouse (Rat orexin B) TFA 是一种内源性增食欲素受体 (Orexin receptor) 激动剂。Orexin B, rat, mouse TFA 结合并激活两个密切相关的孤儿 G 蛋白偶联受体 OX1-R 和 OX2-R。Orexin B, rat, mouse TFA 刺激食物摄入和能量消耗,并在睡眠-觉醒调节中发挥重要作用。
生物活性

Orexin B, rat, mouse (Rat orexin B) TFA is an endogenousorexin receptoragonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation[1][2][3].

体外研究
(In Vitro)

OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50of 36 nM in the binding assay and an EC50of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50in the competitive binding assay and the EC50in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2].

体内研究
(In Vivo)

Orexin-B modulates the activity of rod bipolar cells (RBCs) located in the outer retina of rat. Intravitreal injection of orexin-B increased the amplitude of the scotopic electroretinographic b-wave, a reflection of RBC activity, recorded in vivo[4].

分子量

3050.42

性状

Solid

Formula

C128H216F3N45O36S

Sequence Shortening

RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 100 mg/mL(32.78 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM0.3278 mL1.6391 mL3.2782 mL
5 mM0.0656 mL0.3278 mL0.6556 mL
10 mM0.0328 mL0.1639 mL0.3278 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。