包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
生物活性 | Orexin B, rat, mouse (Rat orexin B) TFA is an endogenousorexin receptoragonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation[1][2][3]. | ||||||||||||||||
体外研究 (In Vitro) | OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50of 36 nM in the binding assay and an EC50of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50in the competitive binding assay and the EC50in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2]. | ||||||||||||||||
体内研究 (In Vivo) | Orexin-B modulates the activity of rod bipolar cells (RBCs) located in the outer retina of rat. Intravitreal injection of orexin-B increased the amplitude of the scotopic electroretinographic b-wave, a reflection of RBC activity, recorded in vivo[4]. | ||||||||||||||||
分子量 | 3050.42 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C128H216F3N45O36S | ||||||||||||||||
Sequence Shortening | RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 100 mg/mL(32.78 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |