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YNT-185 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
YNT-185 dihydrochloride图片
CAS NO:1804978-82-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
YNT-185 dihydrochloride 是一中非肽类的,选择性食欲素 2 型受体(OX2R)激动剂,对 OX2R 和 OX1R 的EC50分别为 0.028 和 2.75 μM。YNT-185 dihydrochloride 改善小鼠模型的发作性瘫痪症状。
生物活性

YNT-185 dihydrochloride is a nonpeptide, selectiveorexin type-2 receptor (OX2R)agonist, withEC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models[1][2].

IC50& Target[1]

OX2Receptor

0.028 μM (EC50)

OX1Receptor

2.75 μM (EC50)

体内研究
(In Vivo)

YNT-185 dihydrochloride (20-40 mg/kg; i.p.) increases wakefulness in mice[2].
YNT-185 dihydrochloride (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice[2].

Animal Model:Male wild-type C57BL/6J mice[2]
Dosage:20, 40 mg/kg
Administration:I.p.
Result:Wake time was also significantly increased.
分子量

688.66

性状

Solid

Formula

C33H39Cl2N5O5S

CAS 号

1804978-82-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)