CAS NO: | 205640-91-1 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Orexin B, human is an endogenous agonist atOrexinreceptor withKis of 420 and 36 nM for OX1 and OX2, respectively. |
IC50& Target | Ki: 420 nM (OX1), 36 nM (OX2)[1] |
体外研究 (In Vitro) | Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor[1]. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50of 36 nM in the binding assay and an EC50of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50in the competitive binding assay and the EC50in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2]. |
体内研究 (In Vivo) | Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively[2]. |
分子量 | 2899.34 |
Formula | C123H212N44O35S |
CAS 号 | 205640-91-1 |
Sequence | Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 |
Sequence Shortening | RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |