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Orexin B,human
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:205640-91-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Human orexin B
产品介绍
Orexin B, human是Orexin受体的内源性激动剂,与OX1和OX2结合的Ki值分别为 420 和 36 nM。
生物活性

Orexin B, human is an endogenous agonist atOrexinreceptor withKis of 420 and 36 nM for OX1 and OX2, respectively.

IC50& Target

Ki: 420 nM (OX1), 36 nM (OX2)[1]

体外研究
(In Vitro)

Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor[1]. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50of 36 nM in the binding assay and an EC50of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50in the competitive binding assay and the EC50in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2].

体内研究
(In Vivo)

Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively[2].

分子量

2899.34

Formula

C123H212N44O35S

CAS 号

205640-91-1

Sequence

Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

Sequence Shortening

RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.