2-Methylthio-AMP diTEA

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1227193-98-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

2-MeSAMP diTEA
2-Methylthioadenosine 5′-monophosphate diTEA
2-Methylthioadenosine 5′-phosphate diTEA

产品介绍

2-Methylthio-AMP (2-MeSAMP) diTEA 是一种选择性和直接的P2Y₁₂拮抗剂。2-Methylthio-AMP diTEA 是 ADP 依赖性血小板聚集的抑制剂。

生物活性

2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and directP2Y₁₂antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation^[1]^[2]^[3].

IC₅₀& Target

P2Y12 Receptor

体外研究
(In Vitro)

2-Methylthio-AMP (2-MeSAMP) diTEA inhibits agonist-mediated α_IIbβ₃activation in platelets^[1].
2-methylthio-AMP (50 μM; for 5 minutes) diTEA does not significantly inhibit thrombin, PAR1-AP, PAR4-AP, or ADP-mediated platelet Ca²⁺mobilization. 2-methylthio-AMP diTEA fails to inhibit Ca²⁺mobilization in P2Y₁₂-deficient mouse platelets and does not raise cAMP or induce vasodilator-stimulated phosphoprotein phosphorylation in wild-type platelets^[1].

分子量

595.69

性状

Solid

Formula

C₂₃H₄₆N₇O₇PS

CAS 号

1227193-98-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)