MRS2179 tetrasodium

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MRS2179 tetrasodium

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1454889-37-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

MRS2179 tetrasodium 是一种竞争性P2Y1受体拮抗剂，对火鸡 P2Y1 受体的K_b值为 102 nM，pA₂为 6.99。MRS2179 tetrasodium 对 P2Y1 的选择性高于 P2X1 (IC₅₀=1.15 μM)、P2X3 (12.9 μM)、P2X2、P2X4、P2Y2、P2Y4 和 P2Y6 受体。MRS2179 tetrasodium 抑制血小板聚集。

生物活性

MRS2179 tetrasodium is a competitiveP2Y1receptor antagonist, with aK_bof 102 nM and apA₂of 6.99 for turkeyP2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC₅₀=1.15 μM), P2X3 (12.9 μM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors^[1]^[2]. MRS2179 tetrasodium inhibits platelet aggregation^[3].

体内研究
(In Vivo)

MRS2179 (50 mg/kg; i.p.) prolongs the bleeding time^[3].

Animal Model:	CL57BLr6 mice^[3]
Dosage:	50 mg/kg
Administration:	Injection into the jugular vein of mice
Result:	The bleeding time, which reflects in vivo primary haemostasis, was significantly prolonged in MRS2179-treated mice, 30 s after injection of MRS2179.

分子量

513.16

Formula

C₁₁H₁₃N₅Na₄O₉P₂

CAS 号

1454889-37-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.