CAS NO: | 936112-69-5 |
规格: | ≥98% |
包装 | 价格(元) |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
GSK3 inhibitor XV is the racemate of (R)-GSK3 inhibitor XV and (S)-GSK3 inhibitor XV. (R)-GSK3 inhibitor XV inhibits glycogen synthase kinase (GSK) 3α and β (IC50s = 0.35 and 0.55 nM, respectively). It selectively inhibits GSK3α and β over a kinase panel including MSK1, RSK1, and TRKA (IC50s = 3,000, 8,000, and 350 nM, respectively), however, it also inhibits PIM-1 with an IC50 value of 35 nM. (R)-GSK3 inhibitor XV (1 μM) disrupts development of the anterior and posterior termini in zebrafish embryos. (S)-GSK3 inhibitor XV is less potent than the (R)-enantiomer, is selective for PIM-1 over GSK3 (IC50s = 3, 80, and 90 nM for PIM-1, GSK3α, and GSK3β, respectively), and has no effect on zebrafish embryonic development.
纯度:≥98%
CAS:936112-69-5