CAS NO: | 2750570-55-7 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | BI-0474 is a potentKRASG12Cinhibitor with anIC50value of 7.0 nM for theGDP-KRAS::SOS1protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying theG12Cmutation. BI-0474 also shows good anti-tumour activity in non-small cell lungcancerxenograft models[1]. | ||||||||
IC50& Target |
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体外研究 (In Vitro) | BI-0474 (1-10,000 nM; 3 days) shows potent antiproliferative activity of 26 nM on NCI-H358 cells carrying a G12C mutation[1]. Cell Proliferation Assay[1]
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体内研究 (In Vivo) | BI-0474 (40 mg/kg; i.p.; single daily for 3 days) shows anti-tumor efficacy and pharmacodynamic biomarker modulation in an NCI-H358 cell line-derived non-small cell lung cancer xenograft model[1].
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分子量 | 587.74 | ||||||||
Formula | C30H37N9O2S | ||||||||
CAS 号 | 2750570-55-7 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |