Somatostatin-28(sheep)

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

73032-94-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Somatostatin-28 (sheep) 是一种生物活性多肽，在近端肠上皮细胞中合成。Somatostatin-28 (sheep) 抑制葡萄糖刺激的胰岛素分泌而不影响循环基础胰岛素浓度。Somatostatin-28 (sheep) 也靶向生长抑素受体 5 亚型 (SSTR5) 调节 GLP-1 分泌。

生物活性

Somatostatin-28 (sheep) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep) suppresses glucose-stimulatedinsulinsecretion without affecting circulating basalinsulinconcentration. Somatostatin-28 (sheep) also targets tosomatostatin receptorsubtype 5(SSTR5) to regulateGLP-1secretion^[1]^[2].

IC₅₀& Target^[2]

SSTR5

体外研究
(In Vitro)

Somatostatin-28 剂量依赖地抑制胃泌素释放肽刺激的 GLP-1 分泌，EC₅₀为 0.01 nM^[1]。

体内研究
(In Vivo)

Somatostatin-28 (sheep) (1.1 pmol/kg/min; 通过颈静脉导管静脉注射; 15 min) 抑制 25 μg/kg/min 葡萄糖诱导绵羊胰岛素分泌^[2]。

Animal Model:	Finn-Dorset Horn cross bred sheep (2-5 years old, 70-75 kg)^[2]
Dosage:	1.1 pmol/kg/min for 15 min, with or without 25 μg/kg/min glucose;
Administration:	Intravenous injection via a jugular catheter;
Result:	Significantly inhibited insulin secretion, resulted serum concentrations decreasing from about 200 to 150 pmol/L.

分子量

3148.56

Formula

C₁₃₇H₂₀₇N₄₁O₃₉S₃

CAS 号

73032-94-7

Sequence Shortening

SANSNPAMAPRERKAGCKNFFWKTFTSC (Disulfide bridge:Cys17-Cys28)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.