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Veldoreotide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Veldoreotide图片
CAS NO:252845-37-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
DG3173
PTR-3173
产品介绍
Veldoreotide (DG3173) 一种生长抑素类似物,可结合并激活生长抑素受体 (SSTR) 2/4/5。与 Octreotide (HY-P0036) 相比,Veldoreotide 在腺瘤中抑制生长激素分泌的比例更高。Veldoreotide 有被用作镇痛剂的潜力。
生物活性

Veldoreotide (DG3173) a somatostatin analogue, that can bind to and activate thesomatostatin receptors (SSTR) 2, 4, and 5. Veldoreotide inhibitsgrowth hormone (GH)secretion in adenomas compared withOctreotide(HY-P0036). Veldoreotide has the potential to be used as pain modulating agent[1]

IC50& Target[1]

SSTR2

37.6 ± 4.5 nM (EC50)

SSTR3

31.3 ± 14. nM (EC50)

SSTR4

10.5 ± 3.4 nM (EC50)

体外研究
(In Vitro)

Veldoreotide stimulates the SST2, SST4, and SST5 receptors with high potency and efficacy in the HEK293 cells, co-expressing these receptors with the GIRK2 channels; EC50s of 37.6 ± 4.5 nM, 31.3 ± 14.4 nM and 10.5 ± 3.4 nM for GIRK2-SST2, GIRK2-SST4 and GIRK2-SST5, respectively[1].
Veldoreotide (10 μM; 24 h) inhibits SST4-expressing BON-1 cells[1].
Veldoreotide (DG3173) (100 nM or 1 μM; 6 h) inhibits GH secreation in adenomas with an IC50of 0.49 nM[2].

Cell Proliferation Assay[1]

Cell Line:SST4-expressing BON-1 cells
Concentration:10 μM
Incubation Time:24 h
Result:Inhibited SST4-expressing BON-1 cells, while did not significantly inhibited wild type BON-1 cells.
Clinical Trial
分子量

1123.30

Formula

C60H74N12O10

CAS 号

252845-37-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.